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History

During the 1980's a gemologist complained to the writer, of the treatment of precious and semi-precious stones by X and gamma radiation which displaced certain impurities and thus artificially created a higher quality gemstone.
Studies in X-radiation also demonstrated that if the electron gun was made of soft metal the atoms of the gun would migrate and track along the path of the X-ray stream. For this reason, the gun is made of tungsten. This was only of academic interest, as the system could not be applied to human patients.
Dr. Cyril Adler, founder and curator of the Adler Museum of the History of Medicine suggested that the system could have possibilities if the X and gamma rays could be neutralized and the alpha and beta rays were used, the problem then would simply be that of dosage, which would be minute.

Transdermal Iontophoresis

In 1890 Thomas Edison suggested that iontophoresis could transport medication through the skin. This idea was followed up by Nikola Tesla in 1890. At the time the technology was not available to construct such a unit. Up till the 1960’s this system was practiced by physiotherapists using Histamine Dihydrochloride for fractures, sprains etc. Histamine Dihydrochloride when used on a patient prone to asthma etc. (Brought on a full asthma attack) The side effect of this system were a) Deep seated slow healing burns. b) Skin rashes caused by heat generated by iontophoresis. c) High amperage made treatment dangerous, (10 milliamps per square inch) and therefore unsuitable for patients with pace makers etc. From 1910 until 1960 crude machines were used for treating injuries, and the name changed with time from Ionization to Electrophoresis and Iontophoresis. During the 1960’s and 70’s the system fell into disuse as the result of its expense, side-effects and need for constant monitoring.

Particle Transport

In 1996 Maxwell et al studied the Iontophoresis System and looked for more efficient and safer delivery systems. He found that particle transfer was safer and more rapid. They therefore began trials using acyclovir as the medication using particle induction to “inject” transport the medication through the skin directly into the infected cell.
In 1997, using the Lectroject Machine, a patient suffering from allergic asthma was treated with diphenhydramine, a drug having a molecular structure similar to histamine. Prior to this treatment, she had been using a cocktail of antihistamines and corticosteroids in increasing dosages and suffering from the side effects of these drugs to the point where the medication she was taking caused additional problems requiring even further medication to be added.
With the Lectroject System, she was able to withdraw completely from her previous regime and control her condition with one treatment per week.
Following this success, we advertised for volunteers for trials to take place at Benmed Park Hospital. Trials were blind with ten patients receiving medication and ten with placebo. Trials were conducted twice weekly over a period of three months.
The final result was:
Placebo Group - 25% reduction in previous medication.
Medicated Group - 48, 02% reduction in previous medication.
The major problem with asthma treatment was the absence of provable scientific evidence.
The next problem to be addressed was that of pain. The first drugs used were fentanyl and alfentanil, these medications are claimed to be 100 times more potent than pethidine. The results were poor, little or no relief was reported.
The next medication to be used was tetracaine, which gave excellent results.
Trials were carried out on runners who were unable to compete in the Comrades Marathon through injuries. Twenty were treated, all entered the race, and all completed it.
Once again, the problem experienced was no provable data.
The system did not make any significant difference in arthritis.

During 2000 with the advantage of Cryotechnology and Particle flow research, Lectroject became possible. This system was perfected in 2001 at which time it went to trial. In 2003 the system was reported in the Medical Cronical as a significant advance in virology. This put Iontophoresis vs. Particle Induction in the same category as transport via donkey cart to transport via train or truck.